Hh-Ag1.5 (SAg1.5) 是一種有效的 Hedgehog (Hh) 激動劑，EC50 為 1 nM。Hh-Ag1.5 介導(dǎo)的重編程打破了非損傷肝臟干細(xì)胞的靜止?fàn)顟B(tài)，從而挽救了肝衰竭。

    HhAg1.5 (5微米；3周)促進(jìn)從體外非損傷肝臟富集的靜止CD133+ CD45-肝干細(xì)胞(Hh3A細(xì)胞)的顯著擴(kuò)增[2]。Hh-Ag1.5完全與含Smo的膜結(jié)合，Ki值為0.52 nM[3]。Smo激動劑SAG-1.5顯示出納摩爾量級的Gli反應(yīng)性報(bào)道活性的效力刺激，EC50為7 nM[4]。

產(chǎn)品性質(zhì)：

Cas No.:612542-14-0

別名 SAg1.5

分子式:C28H26ClF2N3OS

分子量:526.04

溶解度:DMSO : 50 mg/mL (95.05 mM; Need ultrasonic)

儲存條件:Store at -20°C

注意事項(xiàng)：

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References:

[1]. Randall W King. Roughing Up Smoothened: Chemical Modulators of Hedgehog Signaling. J Biol. 2002 Nov 6;1(2):8.

[2]. Abhisek Mitra, et al. A Small Molecule Hedgehog Agonist HhAg1.5 Mediated Reprogramming Breaks the Quiescence of Noninjured Liver Stem Cells for Rescuing Liver Failure. Transl Res. 2019 Mar;205:44-50.

[3]. Maria Frank-Kamenetsky, et al. Small-molecule Modulators of Hedgehog Signaling: Identification and Characterization of Smoothened Agonists and Antagonists. J Biol. 2002 Nov 6;1(2):10.

[4]. Cynthia M Rominger, et al. Evidence for Allosteric Interactions of Antagonist Binding to the Smoothened Receptor. J Pharmacol Exp Ther. 2009 Jun;329(3):995-1005.